Comparative evaluation of the effectiveness of bioresorbable collagen membrane in combination with deproteinized bovine bone matrix xenograft (DBBM), and advanced platelet rich fibrin membrane in combination with deproteinized bovine bone matrix xenograft for periodontal regeneration

Introduction: Periodontitis is a chronic, multifactorial, inflammatory disease that leads to gradual loss of bone and periodontal attachment. Thus, surgery required according severity diseases. The goal reconstructive regenerate soft hard tissues destroyed during disease. Aim: To compare the effectiveness bioresorbable collagen membrane in combination with Deproteinized Bovine Bone Matrix xenograft (group A); Advanced Plasma rich fibrin(A-PRF) B) treatment human infrabony defects. Methods: This randomised controlled trial will be carried out at periodontics outpatient department. We choose 24 patients moderate advanced chronic periodontitis who are otherwise systemically healthy. Infrabony defects treated by open flap debridement using bovine-derived A) A-PRF after completion first therapy B). At baseline six months undergoing surgery, probing pocket depth, clinical attachment level, radiographic fill, gingival recession, oral hygiene status, health measured. Expected results: It suggested Bioresorbable Collagen Membrane show better results as compared Platelet Rich Fibrin Xenograft. Clinical registry India (CTRI): REF/2023/05/066732. Protocol version: v1 (12/05/23)